Small bowel transplantation.
نویسندگان
چکیده
After struggling for three decades, SBT is finally emerging as a clinical reality. To become the standard therapy for the treatment of end-stage intestinal failure, SBT must offer a better quality of life, fewer risks, and lower costs than home TPN. To achieve this standard, protocols must be refined to obtain lower rates of rejection and infection as well as more consistent graft function.
منابع مشابه
Successful orthotopic small bowel transplantation with short-term FK 506 immunosuppressive therapy.
A LTHOUGH small bowel transplantation is the physiologic treatment of the short bowel syndrome, Its clinical implementation awaits development of immunosuppressive regimens that ensure satisfactory control of graft rejection. Agents such as Cy A and corticosteroids are useful for transplantation of most other vascularized organ allografts. However, rejection of the transplanted small intestine ...
متن کاملInfectious complications after small bowel transplantation in adults: an update.
Between May 1990 and February 1995,29 adult patients underwent small bowel Tx in the Transplantation Institute, University of Pittsburgh. Fifteen patients underwent small bowel transplant (SBTx),8 had small bowel together with liver transplant (SBTx/L), and 6 patients underwent multi-visceral Tx (MY), which included SBTx/L together with other organs. In 11 patients (8 SBTx, 3 MY) Tx of the bowe...
متن کاملGraft-versus-host reaction in small-bowel transplantation and possibilities for its circumvention.
To study graft-versus-host reaction (GVHR) in small-bowel transplantation and its underlying mechanisms and to find methods for circumventing GVHR, we used an unidirectional GVHR model in which F1 Lewis (LEW) x Wistar King A (WKA) hybrid rats received small-bowel transplants from either LEW or WKA parent rats. The survival time of F1 hybrid rats that received full-length small-bowel transplanta...
متن کاملDeceased donor liver transplantation performed one week after small bowel resection for complicated umbilical hernia: a case report
Emergent abdominal surgery in cirrhotic patients with ascites can result in dismal postoperative outcomes such as sepsis and hepatic failure. In the present case, small bowel resection followed by anastomosis by the hand-sewn method was performed for small bowel strangulation caused by an umbilical hernia; deceased donor liver transplantation was performed one week after the bowel resection bec...
متن کاملAdvances in small bowel transplantation.
Small bowel transplantation is a life-saving surgery for patients with intestinal failure. The biggest problem in intestinal transplantation is graft rejection. Graft rejection is the main reason for morbidity and mortality. Rejection has a negative effect on the survival of the graft. While 50%-75% of small bowel transplantation patients experience acute rejection, chronic rejection occurs in ...
متن کاملPersistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation.
GRAFf-versus-host disease (GVHD) has always been a concern associated with small bowel transplantation, because of the large amount of matured lymphocytes contained in the graft. In clinical organ transplantation GVHD is not a common complication; however, it is usually fatal once developed. Because there is no suitable experimental model of GVHD associated with solid organ transplantation, stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Transplant immunology
دوره 2 2 شماره
صفحات -
تاریخ انتشار 1992